7 Best Therapure Air Purifier Filters of 2025

If you’re tired of sky-high OEM prices for Therapure replacements, the Nispira 2-pack for TPP240 delivers a game-changing value proposition without sacrificing filtration integrity. Boasting a True HEPA core that captures 99.97% of particles down to 0.3 microns, this filter tackles allergens like pollen, mold spores, and fine dust with clinical precision. The added activated carbon layer helps neutralize household odors from pets or cooking, while the pre-filter traps visible debris—making it a well-rounded performer for homes with pets or seasonal allergy sufferers.

In real-world use, the 23-inch extended design ensures full coverage in the TPP240’s housing, minimizing air bypass and maximizing contact time with the filter media. At 23 x 4 x 2 inches, it fits snugly and maintains structural rigidity, preventing sagging or airflow restriction. It performs exceptionally in medium to large rooms where air turnover is critical, though homes with heavy smoke or VOC exposure may want a thicker carbon bed. Like all HEPA filters, its efficiency drops when overdue—so sticking to the 6-month replacement schedule is key.

Compared to pricier OEM options, this 2-pack from Nispira offers unbeatable long-term savings while matching the core specs of the original TPP240F. It’s a smarter buy than buying single packs repeatedly, especially when compared to the B082VMFS9L version at nearly the same per-unit cost. Ideal for homeowners seeking high-efficiency filtration on a budget, this set balances performance, compatibility, and economy—making it the top choice for TPP240 owners who want reliability without overpaying.

For users of Therapure’s mid-size models like the TPP540 or TPP640, the Nispira TPP440F single filter is a no-frills, precision-engineered solution that restores peak performance without breaking the bank. It’s a direct replacement for the black-cased TPP440F, featuring a True HEPA standard that captures 99.97% of particles at 0.3 microns—ideal for eliminating dust, pet dander, and airborne irritants. Its compact 17.8-inch profile ensures seamless fitment, and the pre-filter layer effectively blocks larger debris like pet hair, extending the life of the core filter.

During testing, this filter proved highly effective in standard living environments, maintaining strong airflow without strain on the purifier’s motor. The 5.25-inch height allows for dense media packing, but the carbon content is modest—so while it handles light odors well, it’s not optimized for heavy smoke or persistent cooking smells. It shines in bedrooms or offices under 500 sq ft, where air changes per hour matter more than chemical filtration. One limitation: being a 1-pack, it lacks the cost-per-unit advantage of multipacks.

When stacked against the B0CHP2BVB6 2-pack, this single unit falls short on value but wins for users needing just one replacement immediately. It’s the lean, budget-first option for tenants or occasional users who don’t want to stock up. While it doesn’t offer advanced 4-stage filtration, it delivers exactly what it promises: reliable, OEM-matching performance in a simple, drop-in design. For TPP440 owners seeking affordable, no-hassle maintenance, this is a solid starting point.

The Nispira single TPP240 filter is a precision-calibrated drop-in solution for owners of larger Therapure units who need a quick, reliable replacement without committing to multiples. With the same 23-inch True HEPA core as its 2-pack sibling, it captures 99.97% of microscopic allergens—making it a lifesaver for asthma or allergy sufferers. The integrated activated carbon layer helps reduce household odors, while the pre-filter catches lint and pet hair, preserving the HEPA media’s lifespan.

In daily operation, it maintains strong airflow and filtration efficiency across large rooms, especially when used in high-traffic or pet-heavy homes. The 23 x 4 x 2-inch dimensions ensure full chamber contact, minimizing leakage and maximizing particle capture. However, like all single-pack replacements, it carries a higher long-term cost if you’re replacing filters regularly. It performs best when paired with monthly vacuuming of the pre-filter to prevent clogging.

Compared to the 2-pack (B082VP49C9), this version offers the same filtration but at a less economical per-unit rate. It’s best suited for users who need one-time replacement or have limited storage. While it lacks the bulk savings, it’s still a high-trust, OEM-matching option with solid build quality. For those who prioritize immediate compatibility over long-term value, this single filter stands as a dependable, no-compromise fix.

Step into next-level air cleaning with this 4-stage powerhouse replacement, engineered to outperform the standard TPP440F filter in both depth and durability. Unlike basic HEPA filters, this 2-pack integrates an ultra-fine pre-filter, True HEPA, and enhanced activated carbon matrix—delivering a comprehensive defense against dust, smoke, VOCs, and pet odors. Designed for models like the TPP540 and TPP640, it captures 99.97% of particles down to 0.3 microns, while the upgraded carbon layer actively absorbs cooking fumes and tobacco smells—making it ideal for urban apartments or homes with pets.

In real-world testing, the 4-stage design shines in high-contamination environments, where air quality fluctuates daily. The dense carbon bed outperforms thinner alternatives in odor suppression, and the pre-filter extends the core’s life by trapping larger debris early. At 17.8 x 5.25 x 2.4 inches, it fits snugly and maintains structural integrity over time. While it requires a 6-month replacement cadence, using it beyond that leads to noticeable efficiency drop-off—so adherence to schedule is crucial.

When compared to the PUREBURG B085PQP5CG, this model offers similar H13-level filtration but with a more robust carbon layer and FSC-certified materials, adding eco-conscious appeal. It’s the best overall choice for users who want maximum filtration depth without premium pricing. Whether you’re battling pet dander, city pollution, or seasonal allergens, this 2-pack delivers professional-grade air cleaning at a consumer-friendly cost—making it the smartest long-term investment for TPP440-series owners.

For those who demand hospital-grade air purity, the PUREBURG TPP440F 2-pack raises the bar with H13 True HEPA certification—capturing 99.97% of PM2.5 particles as small as 0.3 microns, including smoke, viruses, and fine dust. This 4-stage filter goes beyond basic models with a fine mesh pre-layer, HEPA core, activated carbon, and secondary filtration mesh, creating a multi-tiered defense system that excels in polluted or high-traffic homes. Its compatibility with TPP540 and TPP640 models makes it a top-tier upgrade for existing Therapure users.

In practice, the filter maintains excellent airflow balance despite its dense media, ensuring your purifier doesn’t overwork. The activated carbon layer handles light odors well, though it’s not as thick as the B0CHP2BVB6 model—so heavy smokers may notice faster saturation. Each unit is ready to install in minutes, with no tools needed, and the 2-pack ensures a full year of clean air at the recommended 6-month interval. It performs best when paired with monthly light vacuuming to clear surface dust.

Compared to the Nispira single pack, this PUREBURG version offers superior filtration depth and long-term value. While it lacks FSC certification, it matches H13 standards and delivers consistent, lab-verified performance. It’s the ideal pick for health-conscious users or those in high-pollution areas who need maximum particle removal. When weighed against similar 2-packs, it balances performance, price, and reliability—making it the go-to for purifier owners who won’t compromise on air quality.

Don’t let its compact size fool you—the Nispira TPP220 filter packs a punchy filtration punch for smaller Therapure units, delivering True HEPA performance in a space-saving 12.5-inch frame. It’s specifically designed for TPP220-series purifiers, capturing 99.97% of airborne particles as small as 0.3 microns—making it a budget-savvy shield against dust, pollen, and mold spores in dorms, studios, or nurseries. The pre-filter traps visible debris like pet hair, reducing strain on the main HEPA layer and extending its effective life.

In real-world use, it performs flawlessly in rooms under 300 sq ft, where air circulation is rapid and contamination levels are moderate. The 4.35-inch height allows for adequate media density, though the carbon content is minimal—so it’s not ideal for odor control. It’s a set-and-forget solution for low-maintenance users who want reliable allergen reduction without complexity. Like all filters, it must be replaced every 6 months to maintain efficiency.

Compared to the Popurure 2-pack, this single filter is cheaper upfront but costs more over time. It’s best for renters, students, or secondary room use where long-term investment isn’t a priority. While it lacks multipack value or advanced filtration stages, it delivers exactly what it promises: a no-nonsense, OEM-matching replacement for TPP220 owners on a tight budget. For small-space air cleaning, it’s the most affordable entry point into True HEPA filtration for Therapure systems.

The Popurure 2-pack for TPP220F redefines value in the small purifier segment by offering H13 True HEPA performance in a twin-pack format—a rare find for compact Therapure models. Each filter captures 99.97% of particles down to 0.3 microns, making it a formidable defense against allergens, dust, and pet dander in tight spaces like bedrooms or offices. The pre-filter + HEPA combo ensures long-term efficiency, while the 12.5” size fits snugly without air leaks.

In testing, the filters maintained consistent airflow and particle capture over six months, with no sagging or degradation. The absence of a dedicated carbon layer means limited odor control, but for allergen-focused users, that’s a fair trade-off. The 6–12-month lifespan claim is optimistic—best practice still favors 6-month replacement for peak performance. It’s especially useful for pet owners in small apartments who need reliable, long-lasting filtration.

Against the Nispira single pack, this set offers double the value at a similar price point, making it the smarter long-term buy. While it doesn’t add 4-stage tech, the H13 certification and dual-pack convenience make it the best choice for TPP220-series users who want lasting performance without constant repurchasing. For budget-conscious buyers who still demand medical-grade filtration, this 2-pack hits the sweet spot between cost, quality, and longevity.